“People who appreciate the beauty of mathematics activate the same part of their brain when they look at aesthetically pleasing formula as others do when appreciating art or music, suggesting that there is a neurobiological basis to beauty.” https://www.ucl.ac.uk/news/2014/feb/mathematical-beauty-activates-same-brain-region-great-art-or-music

Significant breakthroughs like this often require someone creative or ingenious to first ask “What if there is a connection between A and B?” and to then push forward to do research.